I ordered antihyrdal a little over a week ago and have been using it for about 10 days, applying it every night before I go to bed. I have moderate to severe hand sweating, so I was not expecting this product to be a silver bullet. Over the past 10 days I have definitely noticed a decrease in sweating, particularly in the middle of the hand; the fingertips still get damp. It is winter right now in Chicago (and rather cold right now), so obviously my hands will sweat less than during the summer. In other words, I don't know how effective this will be in the hot and humid days of a Chicago summer.

I do highly recommend combining treatments, such as using iontophoresis and using a topical before bed time (antihydral, drysol, etc...). I have not yet tried this, however.

Here is a link to a study of the effectiveness of Topical Methenamine, one of the active ingredients in Antihydral.

I do imagine that Antihydral would be extremely effective for people with mild to moderate palmar hyperhidrosis.

Article:
"A case of isolated axillary hyperhidrosis successfully treated topically with 1% glycopyrronium cream - Clinical and Experimental Dermatology, November 2006"

Comments:
There are a few more articles related to using Glycopyrronium cream topically, which I will post in time. Pharmacy.ca's "Secure Wipes" are an example of tropical Glycopyrronium. I ordered these in the past at the strongest concentration (3.0%) to try on my hands - I noticed little relief. However, I have read that people have had success applying it to their forehead. I imagine that a cream would be easier to apply than the "Secure Wipes" oxypad type applicators. In any case, I wonder why products like Drysol don't come in a cream as well....it seems that they would absorb more efficiently.

Article:
"Botox delivery by Iontophoresis - British Journal of Dermatology, November 2004"

Further reading:
http://www.sweatsolutions.org/SweatSolutions/Article.asp?ArticleCode=33984200&EditionCode=95129982

Comments:
I personally find this to be one of the most exciting prospective treatments. Iontophoresis is relatively painless...but Botox injections into the hands are terribly painful.

Article:
"Control of Palmar Hyperhidrosis with a New "Dry-Type" Iontophoretic Device - Dermatologic Surgery, January 2007"

Comments:
Apparently there is a 'dry-type' iontophoresis device being tested that does not use tapwater like the Drionic and Fischer devices do.

Anyone who uses iontophoresis can appreciate the impact that a device like this might have. Sitting with your hands submerged in water for 20-30 minutes a day is a pain in the ass to say the least. Though I have no idea what this device looks like, how it is used, or how effective it is (a study with 10 patients is fairly small), this is nonetheless very interesting. Convenience is key!